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It has been adapted in into an anime television series, Shingetsutan Tsukihime , animated by J. Staff , and a manga series, which was serialized between and in MediaWorks ' seinen magazine Dengeki Daioh , with 10 volumes released. Its fame and renown is often attributed to its comprehensive and expansive storyline and its writer Kinoko Nasu 's unique style of storytelling. As well as its anime and manga adaptations, it has also spawned numerous merchandising and memorabilia franchises.

There is some debate as to whether this fluid contains sperm cells. According to Planned Parenthood, if the withdrawal method is performed correctly 100 percent of the time, it is about 96 percent effective. However, most people are not able to perform it correctly every time, making the actual effectiveness somewhere around 78 percent. This means that each year, 22 out of 100 women using this method will get pregnant, or around 1 in 5. Withdrawal is more effective when combined with other methods of contraception, such as male or female condoms or spermicide.